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Posted On: 05/17/2019 11:57:31 AM
Post# of 148892
Was thinking about it some more. I think you are right Misiu.
HAART and leronlimab leave a few residual virus particles undetectable but still floating around. On patients with HAART, after bone marrow transplant from a normal healthy donor, these residual virus particles find the new precursor marrow cells from the donor and reincorporate into then forming new hidden reservoirs of HIV unless maybe the bone marrow is CCR5delta mutation.
With the leronlimab treated patients, however, the new transplanted donor bone marrow cells block the virus from reincorporating due to leronlimab blocking their CCR 5 receptor. After, a few days, all the residual virus dies, and then after you stop leronlimab in a few months, these bone marrow cells now rexpress free CCR5 receptors, but the virus no longer survives to reinfect them. The hidden reservoirs are now gone and the patient is cured.
The strategy is very rational. Sorry for the confusion earlier.
HAART and leronlimab leave a few residual virus particles undetectable but still floating around. On patients with HAART, after bone marrow transplant from a normal healthy donor, these residual virus particles find the new precursor marrow cells from the donor and reincorporate into then forming new hidden reservoirs of HIV unless maybe the bone marrow is CCR5delta mutation.
With the leronlimab treated patients, however, the new transplanted donor bone marrow cells block the virus from reincorporating due to leronlimab blocking their CCR 5 receptor. After, a few days, all the residual virus dies, and then after you stop leronlimab in a few months, these bone marrow cells now rexpress free CCR5 receptors, but the virus no longer survives to reinfect them. The hidden reservoirs are now gone and the patient is cured.
The strategy is very rational. Sorry for the confusion earlier.
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