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Posted On: 09/23/2018 4:17:29 PM
Post# of 72443
As you said Brilacidin does not have systemic absorption thru epithelium which means Brilacidin does not have any effect on what is happening under intact mucous membrane in mouth, it needs injured membrane (lesion) to get access there.
Greatly simplifying oral mucositis model by Dr. Stephen Sonis (scientific advisor to IPIX, among others)
Oral mucositis develops as follows
1 Initiation: radiation and chemotherapy injure DNA causing strand breaks and that way death of epithelial cells. But most tissue damage is caused by reactive oxygen species (ROS, superoxides) generated by radiation.
2 Signaling and Amplification: Initial cell response to damage induces molecules that will eventually cause amplification of damage
3 Ulceration: cell deaths reach threshold for ulceration. Bacteria present in ulcerated area cause more inflammation.
4 Healing
Galera’s GC4419 works by reducing amount of reactive oxygen species - in other words it is active only in phase 1. Brilacidin with its minuscule systemic absorption is active only in phases 3 and 4. Combining them should bring better results than can be reached by either one alone.
Cost considerations are different thing, but I think you make a very good point about them. It is the cost of caring for stage 3 or 4 OM patient (stage 4 subject being hospitalized and fed by IV) versus the cost of treatment preventing the patient ending in the situation.
Greatly simplifying oral mucositis model by Dr. Stephen Sonis (scientific advisor to IPIX, among others)
Oral mucositis develops as follows
1 Initiation: radiation and chemotherapy injure DNA causing strand breaks and that way death of epithelial cells. But most tissue damage is caused by reactive oxygen species (ROS, superoxides) generated by radiation.
2 Signaling and Amplification: Initial cell response to damage induces molecules that will eventually cause amplification of damage
3 Ulceration: cell deaths reach threshold for ulceration. Bacteria present in ulcerated area cause more inflammation.
4 Healing
Galera’s GC4419 works by reducing amount of reactive oxygen species - in other words it is active only in phase 1. Brilacidin with its minuscule systemic absorption is active only in phases 3 and 4. Combining them should bring better results than can be reached by either one alone.
Cost considerations are different thing, but I think you make a very good point about them. It is the cost of caring for stage 3 or 4 OM patient (stage 4 subject being hospitalized and fed by IV) versus the cost of treatment preventing the patient ending in the situation.
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