Nice update. It's clear Washington University in St. Louis is working with the Buck Institute on MANF.

Quote:

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I am aware that we need a breakthrough therapy for Wolfram syndrome.
...
We need something that can reverse symptoms, such as visual impairment, and we need to tap into new technologies. We are developing a regenerative gene therapy, especially for visual impairment. Our strategy is to introduce a regeneration factor into a type of retinal cells using a gene transfer technology. This is clearly not simple and requires a lot of time and efforts, but we are making progress.

As we rise into 2018, I feel that something new and wonderful will happen to us next year. I feel that we will go into a new stage.

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I'll also add Buck got a substantial grant on MANF after they published their positive research.

Harnessing an innate repair mechanism enhances the success of retinal transplantation
June 26, 2016/
http://www.buckinstitute.org/buck-news/harnes...plantation

Amarantus Enters into Research Collaboration with the Buck Institute for Research on Aging for MANF
August 11, 2014
http://www.buckinstitute.org/buck-news/amaran...laboration