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Posted On: 01/05/2018 7:21:44 PM
Post# of 72446
Well there goes my weekend...
Uncovering How Alcohol-derived Metabolites Damage the Genome of Stem Cells
"An additional aspect of this work investigated how the stem cells respond to damage caused by aldehydes. Juan found that most of the stem cells experiencing DNA damage died because of the activation of p53 – a master regulator of cellular stress responses and prime executioner. Removing the p53 gene allowed most of the aldehyde-damaged stem cells to now survive, but unexpectedly this did not seem to lead to a greater burden of genome damage. This result suggests that the critically important p53 stress response in stem cells fundamentally differ from the response seen in other cells."
https://www.technologynetworks.com/tn/news/un...lls-295916
Uncovering How Alcohol-derived Metabolites Damage the Genome of Stem Cells
"An additional aspect of this work investigated how the stem cells respond to damage caused by aldehydes. Juan found that most of the stem cells experiencing DNA damage died because of the activation of p53 – a master regulator of cellular stress responses and prime executioner. Removing the p53 gene allowed most of the aldehyde-damaged stem cells to now survive, but unexpectedly this did not seem to lead to a greater burden of genome damage. This result suggests that the critically important p53 stress response in stem cells fundamentally differ from the response seen in other cells."
https://www.technologynetworks.com/tn/news/un...lls-295916
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