Ok, so I have a question. Based on that PR it sounds like MANF is not a good thing to have and that high levels are associated with insulin resistance. Great that you might be able to use MANF levels to diagnose Type II diabetes, but we already have ways to determine that, ie A1c levels. So, why are elevated MANF levels a good thing? This PR sounds like a negative to me. Of course it could just be that I am always negative...lol. Not!