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MANF is a newly identified protein that is localized to the luminal endoplasmic reticulum (ER). ER stress can stimulate MANF expression and secretion. Evidence suggests that MANF has protective and immunomodulatory effects in different disease models, indicating that MANF may have significant therapeutic potential to treat ER stress-mediated diseases. Recently, Dr. Chen and co-coworkers were the first to discover that MANF is a urinary biomarker of ER stress-related kidney diseases (see here).

“ We will be very interested in investigating the therapeutic role of MANF in kidney diseases, ” says Dr. Chen.

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