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Posted On: 09/24/2017 1:12:27 PM
Post# of 30067
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Thanks Red! Here's a TL;DR
Cerebral ischemia activates endogenous reparative processes such as increased proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) and migration of neural progenitor cells (NPCs) toward the ischemic area. However, this reparative process is limited because most of the NPCs die shortly after injury or are unable to arrive at the infarct boundary. In this study, we demonstrate for the first time that endogenous MANF protects NSCs against oxygen-glucose-deprivation-induced injury and has a crucial role in regulating NPC migration......Taken together, this study determines the effect of MANF in promoting migration of NPCs in vivo and in vitro, and suggests MANF to improve the effectiveness of stem cell-based therapies for a damaged central nervous system.
http://www.cell.com/molecular-therapy-family/...all%3Dtrue
Cerebral ischemia activates endogenous reparative processes such as increased proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) and migration of neural progenitor cells (NPCs) toward the ischemic area. However, this reparative process is limited because most of the NPCs die shortly after injury or are unable to arrive at the infarct boundary. In this study, we demonstrate for the first time that endogenous MANF protects NSCs against oxygen-glucose-deprivation-induced injury and has a crucial role in regulating NPC migration......Taken together, this study determines the effect of MANF in promoting migration of NPCs in vivo and in vitro, and suggests MANF to improve the effectiveness of stem cell-based therapies for a damaged central nervous system.
http://www.cell.com/molecular-therapy-family/...all%3Dtrue
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