I'm telling you buc...options will ruin you if you do not know what you're doing...there's more to them than buying low and selling high...and if you play options with bio-tech stocks you might as well play Russian Roulette. PO's, ADCOMs, FDA rejections, any number of factors Bio-Techs bring to the table can take an option call you're in and flush it down the toilet. Trust me...I had 1000 calls of BPAX before they got approval and then flushed the share holders down the toilet... DSCO, and ARNA, all those Bio-Pharmas with calls are major whores when it comes to giving the calls and puts their dues.  Just looking out for you is all...