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Conclusions

This study revealed that DmManf is involved in Drosophila wing development and expanded our knowledge on the role of MANF in the maintenance of cellular homeostasis. Importantly, we discovered novel genetic interacting partners of DmManf and our study suggests that MANF has a role in mitochondrial function . These data help us understand the molecular mechanism of the evolutionarily conserved MANF/CDNF protein family in future studies.

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What are Mitochondria?

Mitochondria are tiny organelles found in almost every cell in the body.
They are known as the "powerhouse of the cell."
They are responsible for creating more than 90 percent of cellular energy.
They are necessary in the body to sustain life and support growth.
They are composed of tiny packages of enzymes that turn nutrients into cellular energy.
Mitochondrial failure causes cell injury that leads to cell death. When multiple organ cells die there is organ failure.

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