(Total Views: 417)
Posted On: 05/14/2017 5:41:04 PM
Post# of 72446
Re: someconcerns #33783
Another good SLC post:
slcimmuno Member Level Sunday, 05/14/17 05:37:18 PM
Re: Amatuer17 post# 181966
Post # of 181969
Let's be more fair and honest
~3 years ago we had B only in ABSSSI and K only in solid tumors
Now we have:
B OM - Phase 2 (placebo controlled) with interim readout showing possibly the first OM drug that could prevent Severe Ulcers
B IBD - Phase 2 (proof of concept) with interim readout showing Brilacidin in fact works (quite well, per MMDAI and Endoscopy) even when suboptimally formulated
P - Phase 2 (placebo) in mild to moderate with Topline showing 200mg compared favorably to Apremilast and even better among moderate patients
K - Phase 2 (MOA / mapping) safety established in P1 and for those who harped "safe as water" I ask to comment on Kite / Juno ... killing people... now moving on to trying to inform mechanism
So: science has advanced LOTS so much closer to reality, with B now validated as topically effective and safe, suggesting its extension into many other areas/indications.
Re Mngmt - yeah, some missteps but who is perfect? And bringing Dr B in was right call and I'm betting yields results. If/when that first deal is struck, I'd luv to see how folks opinion of management will change ... likely in a heartbeat.
With you and others who seem one foot in and one foot out I've often wondered:
Why Stay In? Why not cut losses and put $ into the other companies you post about?
Biotech masochism prob not the healthiest of life endeavors
slcimmuno Member Level Sunday, 05/14/17 05:37:18 PM
Re: Amatuer17 post# 181966
Post # of 181969
Let's be more fair and honest
~3 years ago we had B only in ABSSSI and K only in solid tumors
Now we have:
B OM - Phase 2 (placebo controlled) with interim readout showing possibly the first OM drug that could prevent Severe Ulcers
B IBD - Phase 2 (proof of concept) with interim readout showing Brilacidin in fact works (quite well, per MMDAI and Endoscopy) even when suboptimally formulated
P - Phase 2 (placebo) in mild to moderate with Topline showing 200mg compared favorably to Apremilast and even better among moderate patients
K - Phase 2 (MOA / mapping) safety established in P1 and for those who harped "safe as water" I ask to comment on Kite / Juno ... killing people... now moving on to trying to inform mechanism
So: science has advanced LOTS so much closer to reality, with B now validated as topically effective and safe, suggesting its extension into many other areas/indications.
Re Mngmt - yeah, some missteps but who is perfect? And bringing Dr B in was right call and I'm betting yields results. If/when that first deal is struck, I'd luv to see how folks opinion of management will change ... likely in a heartbeat.
With you and others who seem one foot in and one foot out I've often wondered:
Why Stay In? Why not cut losses and put $ into the other companies you post about?
Biotech masochism prob not the healthiest of life endeavors
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