there are way too many variables between individuals as well as the COTE stock to make any accurate rule of thumb as to when and how much to take a profit, if at all...

Many are here to see this to the finish line and will live or die with that choice.
Other's are at different time frames in their life and have different financial needs

what may be a good place to take some off the table for one , may not be for another....

Some here could care less(and I will include GC in this) if this stock is trading at a penny or two as they have much bigger goals.

While some here get excited by a few tick moves up and are scared of missing the "next move"

the biggest problem I see is COTE share structure/outstanding shares and lack of proper working capital.

invest what you can afford to lose. If you want to take some off the table - then my advise would be to set targets with GTC trades now and renew them before they expire. Some expire in 30 days , some expire in 60 days,

Then your decision will be made already.