Good find. Entyvio is not a first-line therapy -- it's to be used by people who have tried other stuff and it doesn't work. It's an immune system suppressant, and immune system suppressants typically have the side effects that they mention:

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Although it has not been reported with ENTYVIO, it may be possible for a person to get progressive multifocal leukoencephalopathy (PML) (a rare, serious brain infection caused by a virus). People with weakened immune systems can get PML, which can result in death or severe disability. There is no known treatment, prevention, or cure for PML. Tell your healthcare provider right away if you have any of the following symptoms: confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.
Liver problems can happen in people who receive ENTYVIO. Tell your healthcare provider right away if you have any of the following symptoms: tiredness, loss of appetite, pain on the right side of your abdomen, dark urine, or yellowing of the skin and eyes (jaundice).
The most common side effects of ENTYVIO include common cold, headache, joint pain, nausea, fever, infections of the nose and throat, tiredness, cough, bronchitis, flu, back pain, rash, itching, sinus infection, throat pain, and pain in extremities. These are not all the possible side effects of ENTYVIO. Call your healthcare provider for medical advice about side effects.

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Brilacidin instead works as a powerful ANTI-INFLAMMATORY, not an immune system suppressant. There have been NO safety concerns, and it has a very low rate of getting into the bloodstream (thus, exposing the entire body to it). It seems probable that if approved by the FDA, Brilacidin would become a FIRST-LINE treatment exactly because of the lack of side effects, and the lack of systemic exposure.