For the most part the OTC (such as $RMHB) usually stays unaffected by actions of the federal reserve but at times indirectly it can.

Here is an example:

Margin Calls on investors who are over extended are often effected by bad stock market news such as an interest rate hike. This can have an negative amplification effect if brokerage accounts need to sell off investor holdings to cover the losses generated from a negative market swing.