$CBIS HIV uses our immune system to infect healthy immunogenic cells and increase the opportunity of these cells to spread. HIV-1 proteins (gp120, Tat - the transactivator of transcription, Vpr, and Nef) are released from infected cells throughout the course of infection and create an ongoing HIV disease burden in a number of tissues, including the central nervous system (CNS), resulting in toxicity and damage, regardless of ART.

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