Posted On: 11/02/2016 1:52:55 PM
Post# of 72443
Ziagen has 83% bioavailability. Since 300 mg of Ziagen is bioequivalent to 350 mg of Prurisol, Prurisol has 71% bioavailability.
Ziagen is often prescribed for 600 mg per day, so I don't expect any safety concerns for the 400 mg arm of Prurisol.
600 mg of Ziagen * 0.83 = 498 mg of abacavir in circulation
400 mg of Prurisol * 0.71 = 284 mg of abacavir in circulation
Ziagen is often prescribed for 600 mg per day, so I don't expect any safety concerns for the 400 mg arm of Prurisol.
600 mg of Ziagen * 0.83 = 498 mg of abacavir in circulation
400 mg of Prurisol * 0.71 = 284 mg of abacavir in circulation
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