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Innovation Pharmaceuticals IPIX
Posted On: 10/07/2016 8:20:56 PM
Post# of 72447
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Posted By: sox0407
Re: scgmck1 #28032
Good job! Although APR-246 is ahead of K in OC at the moment, there are concerns on its safety.

"Side effects are a concern because APR-246 binds to the amino acid cysteine and irrevocably changes it—and cysteines are abundant on numerous other proteins besides p53. But so far, Abrahmsen says, APR-246 has been tolerated well in clinical trials, even in relatively high doses. Wiman suspects that this is because the drug's shape makes it interact primarily with the cysteines in the core of mutated p53. But he and his colleagues are now working to confirm this."













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