Posted On: 12/11/2012 7:34:00 PM
Post# of 72433
We don't. First cohort would start at a fraction of the animal MTD. First cohort dosing based fully on preclinical lab work. Privy info till human MTD established. Strong dose not first cohort goal - exploration of safety,tolerability and toxicity first cohort goals. Any positive effect is just huge bonus.
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