They are required to put everything on the disclaimer, but truth is that very few people encounter any of these side effects. Also, many with psoriasis also develop psoriatic arthritis, which Humira treats successfully in most cases. Phil Mickelson isn't lying when he says it's painful. I'll vouch for that. So far, no drug has been a panacea for all the indications for everyone. I doubt one ever will, but for some, the biologics work very well with little or no side effects. I'm one of them. My only downside is a slightly weakened immune system. Nothing old whiskey won't fix.