Posted On: 12/15/2015 10:03:45 PM
Post# of 72440
That's a great point Drano:
I've also wondered if the impact of Kevetrin on the cellular machinery persists well beyond what one would expect based on half lives. In that they are seeing clinical effects with a once weekly dose perhaps suggests this may be the case. I have no idea. To demonstrate clinical efficacy, however, it makes sense to maximize tumor exposure to Kevetrin.
Quote:
Is it possible that Kevetrin "turns on" the gene and the effect lasts much longer than the half-life of the drug even with K no longer being infused, but then wears off?
I've also wondered if the impact of Kevetrin on the cellular machinery persists well beyond what one would expect based on half lives. In that they are seeing clinical effects with a once weekly dose perhaps suggests this may be the case. I have no idea. To demonstrate clinical efficacy, however, it makes sense to maximize tumor exposure to Kevetrin.
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