All of us are losing money on paper (or lost for those that sold)...complaining and b******* about it is not going to get that back. Investing in the OTC is a gamble no matter how good/bad the science/mgmt is. With funding a constant challenge, any wrong decision or risk taken that doesnt produce results will have a bigger impact . If you think the company is at a point where it cannot turnaround, sell with whatever you have and move on. If you still believe in them, then hold/buy and wait for whatever happens next and reevaluate your next investment accordingly.