Posted On: 08/27/2015 12:32:18 PM
Post# of 22463
Nanoparticles Hit Cancer’s Moving Target
Nanomedicine: A nanoparticle that targets two metastatic markers can find cancer cells as they spread from a primary tumor site
Though most cancer therapies treat tumors as monoliths, the cells evolve and change their behavior over time. For example, they can alter their gene expression pattern to escape from the primary tumor and spread throughout the body. Now, researchers have developed a nanoparticle that targets cancer cells at two different stages of metastasis, which could make it possible to prevent the disease from spreading
By packaging small molecule drugs inside nanoparticles, a number of researchers hope to develop therapies that will deliver a highly concentrated dose of a drug only to tumor cells, while sparing healthy tissue. They do this by decorating the drug-carrying nanoparticles with a ligand targeted to a marker found only on cancer cells.
http://cen.acs.org/articles/93/web/2015/08/Na...noFocus%29
Nanomedicine: A nanoparticle that targets two metastatic markers can find cancer cells as they spread from a primary tumor site
Though most cancer therapies treat tumors as monoliths, the cells evolve and change their behavior over time. For example, they can alter their gene expression pattern to escape from the primary tumor and spread throughout the body. Now, researchers have developed a nanoparticle that targets cancer cells at two different stages of metastasis, which could make it possible to prevent the disease from spreading
By packaging small molecule drugs inside nanoparticles, a number of researchers hope to develop therapies that will deliver a highly concentrated dose of a drug only to tumor cells, while sparing healthy tissue. They do this by decorating the drug-carrying nanoparticles with a ligand targeted to a marker found only on cancer cells.
http://cen.acs.org/articles/93/web/2015/08/Na...noFocus%29
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