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Researchers found that these two proteins may signal dysfunction in the choroid plexus, a brain region responsible for the production of CSF. Since such dysfunction is characteristic of Alzheimer’s disease, researchers suggested them as potential biomarkers. Remarkably, the presence of both proteins was also detected in blood samples. “I’ve historically been skeptical that blood can be as strong a predictor of Alzheimer’s disease as CSF, but I was pleasantly surprised to see that there was a reasonable correlation in samples of CSF and blood taken from the same patients,” said Dr. Lovell, who believes that Alzheimer’s disease will ultimately be diagnosed through a set of three or four biomarkers .

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