$MYOS In particular, we are using a systems biologic and metabolic analytic approach to establish the genetic and molecular basis for understanding the regulation of muscle growth and repair. We are using these methods to determine the role of myostatin and other regulatory molecules in the complex communication between skeletal muscle and adipose tissue and their involvement in age-related sarcopenia, disease associated cachexia, diabetes and other complex systemic metabolic diseases including anorexia nervosa. Our collaborative efforts with scientist and physicians from world-class universities and institutions include Harvard Medical School, Hackensack University Medical Center, and GNS Healthcare.