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26 Sep 2014
Soluble factors for regenerative medicine

We are looking for soluble factors in our body that can enhance the regeneration of damaged tissues in Wolfram syndrome and Type 1 diabetes. We have discovered two molecules so far. One of them is MANF.

We are trying to produce a large amount of these factors in the dish (recombinant proteins) and give these factors to animal models and cell models. We are also looking for methods/small molecules (i.e., drugs) to enhance the functions of these factors. This strategy is also related to “regenerative therapy”, but independent of stem cells.

Thank you for reading this. I hope you will have a wonderful Friday. Warmly, Fumi Urano

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28 Sep 2014
Soluble factors for regenerative medicine 2

I received several questions related to my blog of September 26, 2014.
Soluable Factors

How can we utilize MANF, a natural soluble factor produced in our body, to protect and proliferate remaining beta cells and neurons?

The key is to understand how MANF simulates the proliferation and enhances the function of remaining tissues. It seems like there are two independent mechanisms. There are two different mediators for MANF in our body. Thus, our goal is to develop two different types of small molecules to enhance the functions of endogenous MANF. Another option is to inject recombinant MANF. Because of several scientific reasons, we prefer small molecules at the moment.

Thank you for reading this blog. I hope you will have a wonderful and beautiful Sunday. Please feel free to contact me if you have any questions. I am here for you. Take care, Fumi Urano

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