Posted On: 02/02/2015 12:03:40 AM
Post# of 30066
Mesencephalic astrocyte-derived neurotrophic factor and cerebral dopamine neurotrophic factor: new endoplasmic reticulum stress response proteins
Received 7 June 2014, Revised 9 December 2014, Accepted 7 January 2015, Available online 28 January 2015
Conclusions
In summary, MANF and CDNF are exceptional proteins with very different N- and C-terminal domains. The unique structure suggests their unique function. Especially MANF, as an ER stress-inducible genes, plays important roles during ER stress in cells. All of these findings provide insight into the mechanism of MANF and CDNF in protection of progressive diseases associated with ER dysfunction, such as PD and diabetes, which makes them a highly potential therapeutic agent.
Received 7 June 2014, Revised 9 December 2014, Accepted 7 January 2015, Available online 28 January 2015
Conclusions
In summary, MANF and CDNF are exceptional proteins with very different N- and C-terminal domains. The unique structure suggests their unique function. Especially MANF, as an ER stress-inducible genes, plays important roles during ER stress in cells. All of these findings provide insight into the mechanism of MANF and CDNF in protection of progressive diseases associated with ER dysfunction, such as PD and diabetes, which makes them a highly potential therapeutic agent.
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