GNTA News Tesetaxel Clinical Data in Gastric Cancer and Breast Cancer to be Featured at ASCO Annual Meeting

2012-04-04 08:05 ET - News Release

BERKELEY HEIGHTS, N.J., April 4, 2012 (GLOBE NEWSWIRE) -- Genta Incorporated (OTCBB:GNTA) announced today that its lead compound, tesetaxel, will be featured in multiple presentations of new clinical data at the upcoming Annual Meeting of the American Society of Clinical Oncology (ASCO). The meeting will be held June 1-5, 2012, in Chicago, IL.

At the meeting, results from a confirmatory Phase 2 trial of tesetaxel, the leading oral taxane in clinical development, will be reported for overall response and progression-free survival (PFS) when used as 1st-line therapy for patients with hormone-refractory breast cancer. A second Phase 2 trial -- using tesetaxel as 2nd-line therapy for patients with advanced gastric cancer -- will report results on overall response and overall survival. A third presentation will report safety, pharmacokinetics, and the maximally tolerable dose (MTD) from a novel, weekly, dosing schedule. A final presentation will report data from a study of tesetaxel plus capecitabine (Xeloda®; Hoffmann La Roche, Inc.), a drug combination that will be featured in Genta's late-stage clinical trials.

Titles, dates, and times of these presentations appear below.

Tesetaxel: activity of an oral taxane as first-line treatment in metastatic breast cancer. Abstract #1016
Lead author: Andrew Seidman, MD, Memorial Sloan-Kettering Cancer Center
Poster Discussion Session: Breast Cancer - Triple-Negative/Cytotoxics/Local Therapy
Monday June 4, 2012; 1:15-5:45PM
 
Phase II trial of tesetaxel, an oral taxane, as second-line therapy for patients with advanced gastroesophageal cancer. Abstract 4077
Lead author: Mary Mulcahy, MD, Northwestern University
General Poster Session: Gastrointestinal (Non-colorectal) Cancer
Monday June 4, 2012; 8AM-12N