Posted On: 01/14/2015 10:13:13 PM
Post# of 30066
Cancer drug nilotinib may help cure Alzheimer’s disease: It's all in tau
Georgetown University Medical Center researchers say they've found evidence it's the tau rather than the plaque that accelerates neuron death.
As part of their investigation, the researchers looked at the anti-cancer drug nilotinib, approved for used in adult leukemia patients, as a possible treatment to clear out such intercellular debris and control levels on nonfunctioning "bad" tau.
The discovery of the role of tau in Alzheimer's could lead to screening that could uncover signs of the disease at an earlier state and and help predict if a patient is likely to develop dementia , he says.
"Recent evidence suggests it appears that tau modification happens much earlier than amyloid plaques ... and because almost every patient who has tau modification has dementia, it's going to be a much more reliable and precise predictor of Alzheimer's and other dementias than [amyloid-beta], " Moussa says.
http://www.techtimes.com/articles/19280/20141...in-tau.htm
Nilotinib = Tasigna = Novartis Onco
http://www.us.tasigna.com/index.jsp?usertrack...1350551371
Georgetown University Medical Center researchers say they've found evidence it's the tau rather than the plaque that accelerates neuron death.
As part of their investigation, the researchers looked at the anti-cancer drug nilotinib, approved for used in adult leukemia patients, as a possible treatment to clear out such intercellular debris and control levels on nonfunctioning "bad" tau.
The discovery of the role of tau in Alzheimer's could lead to screening that could uncover signs of the disease at an earlier state and and help predict if a patient is likely to develop dementia , he says.
"Recent evidence suggests it appears that tau modification happens much earlier than amyloid plaques ... and because almost every patient who has tau modification has dementia, it's going to be a much more reliable and precise predictor of Alzheimer's and other dementias than [amyloid-beta], " Moussa says.
http://www.techtimes.com/articles/19280/20141...in-tau.htm
Nilotinib = Tasigna = Novartis Onco
http://www.us.tasigna.com/index.jsp?usertrack...1350551371
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