Posted On: 12/01/2014 11:25:41 PM
Post# of 30066
Shhhh, don't tell Dave or he'll start worrying and we'll get our 1,005th post on small molecules, but there appears to be plenty-o-companies manufacturing MANF. This likely has more to do with GMP than finding a company to manufacture it.
Here's the first five I found and there are more.
http://www.peprotech.com/en-US/Pages/Product/...ANF/450-06
http://www.rndsystems.com/Products/3748-mn/Re...nformation
http://www.novoprotein.com/product/MANF_Human.htm
http://www.sinobiological.com/MANF-Protein-g-3731.html
http://www.icosagen.com/products/proteins/12629
Why in the world would so many companies be selling this?
"In the CNS, MANF selectively protects nigral dopaminergic neurons, versus GABAergic or serotonergic neurons, which suggests that MANF may be indicated for the treatment of Parkinson's disease. MANF is also one of the 12 commonly unfolded protein response (UPR)-upregulated genes. One study showed that MANF plays an important role in protecting cells against tunicamycin and thapsigargin-induced cell death. Loss of MANF renders cells more susceptible to those drugs, but also increases cell proliferation and decreases cell size. Another study showed that MANF is an endoplasmic reticulum stress response (ERSR) gene in the heart that can be induced and secreted in response to ER stresses, including ischemia, and that extracellular MANF may protect cardiac myocytes in an autocrine and paracrine manner."
Here's the first five I found and there are more.
http://www.peprotech.com/en-US/Pages/Product/...ANF/450-06
http://www.rndsystems.com/Products/3748-mn/Re...nformation
http://www.novoprotein.com/product/MANF_Human.htm
http://www.sinobiological.com/MANF-Protein-g-3731.html
http://www.icosagen.com/products/proteins/12629
Why in the world would so many companies be selling this?
"In the CNS, MANF selectively protects nigral dopaminergic neurons, versus GABAergic or serotonergic neurons, which suggests that MANF may be indicated for the treatment of Parkinson's disease. MANF is also one of the 12 commonly unfolded protein response (UPR)-upregulated genes. One study showed that MANF plays an important role in protecting cells against tunicamycin and thapsigargin-induced cell death. Loss of MANF renders cells more susceptible to those drugs, but also increases cell proliferation and decreases cell size. Another study showed that MANF is an endoplasmic reticulum stress response (ERSR) gene in the heart that can be induced and secreted in response to ER stresses, including ischemia, and that extracellular MANF may protect cardiac myocytes in an autocrine and paracrine manner."
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