English is my first language and I don't see how any one here doesnt understand your point! You're spot on, dead right on you're interpretation of what Dr. Urano is explaining to us in his blogs. He will use small molecules to stimulate manf in the body to treat wf. Recombinant manf is not a possibility. I applaud your drill down on the matter and understand what you have been desperately trying to get everyone to understand. I will forget all hope that manf will be used for anything because if small molecules will do the trick in stimulating manf inside the body there is no reason why they can't for all diseases manf can possibly treat. It was so simple! I have finally got what you've been trying to say! How did I ever think think otherwise? After all, I have read his blogs regarding his plans to use small molecules. Maybe small molecules can stimulate gdnf in the body too? Many thanks to you for bringing this to light...I will sell tmrw and invest in small molecules instead because we know they will be used instead of recombinant manf. I look forward to tmrw to learn more about this from Dr. Urano. It takes awhile for me to wrap my head around new ideas, even if it is repeatedly brought to my attention via your posts. Everyone on this message board attention please, what Dave L is telling us is Dr. Urano is NOT planning to use Recombinant manf to treat WF. Instead, he is planning to use SMALL MOLECULES to stimulate manf in the body. Everyone got it now? Hopefully this helped your cause, Dave.