no one knows exactly what Dr. Urano is using until he reveals the Data..

But MANF is involved in one way or another in my opinion - we shall find out eventually -

MANF has Data from the Buck Institute as a possible aid in Transplantation

.. Urano's plan calls for Stem cell Transplants ..

no way of counting MANF's involvement out completely

even if its not a cure for Wolfram/ Diabetes.. it may still cure the Vision aspect of the disease - Still HUGE..