Actually it doesn't. There are tons of companies that have great science and approved drugs but those drugs do not sell well as predicted (DNDN, ARNA, GTCB, as examples). You do not need to be an expert to know this. Any well informed investor in biotechs knows this. That's not to say AMBS will not be successful but one does not know until said products are out on the market for the market to decide. As has been pointed out, no one here would have thought 6 months ago or 3 months ago that this stock would be where it is at now. Many posters were 100% sure we'd be trading much higher. How did that all turn out?