Posted On: 09/30/2014 1:57:03 PM
Post# of 30035
Re: the gipper #7439
It's true , Dr, Urano seems to be impressed with MANF. However, I don't like his current preference of using drugs to stimulate the natual production of MANF over injecting recombinant MANF. Hopefully that will change.
"How can we utilize MANF, a natural soluble factor produced in our body, to protect and proliferate remaining beta cells and neurons?
The key is to understand how MANF simulates the proliferation and enhances the function of remaining tissues. It seems like there are two independent mechanisms. There are two different mediators for MANF in our body. Thus, our goal is to develop two different types of small molecules to enhance the functions of endogenous MANF. Another option is to inject recombinant MANF. Because of several scientific reasons, we prefer small molecules at the moment."
"How can we utilize MANF, a natural soluble factor produced in our body, to protect and proliferate remaining beta cells and neurons?
The key is to understand how MANF simulates the proliferation and enhances the function of remaining tissues. It seems like there are two independent mechanisms. There are two different mediators for MANF in our body. Thus, our goal is to develop two different types of small molecules to enhance the functions of endogenous MANF. Another option is to inject recombinant MANF. Because of several scientific reasons, we prefer small molecules at the moment."
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