Posted On: 08/31/2014 3:28:41 PM
Post# of 30036
JP, great reminder again to all of us as to the immense potential for MANF, but especially in regards to Diabetes. We should further note, that MANF does not just have potential but has shown that it is able to actually help in initiate cell proliferation!
"Additionally, we show that lack of MANF in vivo in mouse leads to chronic unfolded protein response (UPR) activation in pancreatic islets. Importantly, MANF protein enhanced β cell proliferation in vitro and overexpression of MANF in the pancreas of diabetic mice enhanced β cell regeneration. We demonstrate that MANF specifically promotes β cell proliferation and survival, thereby constituting a therapeutic candidate for β cell protection and regeneration."
Read More: http://investorshangout.com/post/view?id=1935...z3C02KD55I
"Additionally, we show that lack of MANF in vivo in mouse leads to chronic unfolded protein response (UPR) activation in pancreatic islets. Importantly, MANF protein enhanced β cell proliferation in vitro and overexpression of MANF in the pancreas of diabetic mice enhanced β cell regeneration. We demonstrate that MANF specifically promotes β cell proliferation and survival, thereby constituting a therapeutic candidate for β cell protection and regeneration."
Read More: http://investorshangout.com/post/view?id=1935...z3C02KD55I
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