Posted On: 08/26/2014 10:19:22 AM
Post# of 30067
Journal of the Neurological Sciences
Volume 344, Issues 1–2, 15 September 2014, Pages 129–138
Mesencephalic astrocyte-derived neurotrophic factor prevents neuron loss via inhibiting ischemia-induced apoptosis
Highlights
• MANF prevented neuronal loss induced by ischemia in hippocampus and cortex.
•MANF rescued neural cells from apoptosis induced by focal cerebral ischemia
•MANF repressed the cleavage of caspase-3 triggered by focal cerebral ischemia.
•MANF reduced the elevation of BIP/Grp78, p-IRE1, and XBP1s induced by MACO.
•MANF did not affect the expression of XBP1u and XBP1s mRNA up-regulated by MACO.
http://www.sciencedirect.com/science/article/...0X14004122
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