I am tired of these short-sighted "downers"... Kevetrin is a breakthrough treatment for cancer, AND did we forget LEUKEMIA! WE have European trials coming up too (Yeehah)

“The p53 mechanism of Kevetrin as a possible new therapy for leukemia is very exciting and holds significant promise. After Dr. Menon’s years of hard work, I am impressed with the progress of this novel compound. I look forward to the commencement of human trials and the realization of Kevetrin’s potential as a new therapy for a wide array of cancers.” Dr Emil Frei (ended childhood leukemia)

Data from the NCI-60 DTP Human Tumor Cell Line Screen showed that Kevetrin was effective in killing leukemia cells in vitro. Accordingly, the activity of Kevetrin was evaluated in nude mice bearing established human chronic myelogenous leukemia tumors, K-562. After administration of 200 mg/kg every other day per week for 3 weeks, Kevetrin significantly reduced the average tumor volume by 84% (day 24, p< 0.01). Tumors in mice treated with Kevetrin took a median of 32 days to reach 1000 mm3 in volume whereas control mice took only 15 days, resulting in a Tumor Growth Delay of 110%.  In addition, after Kevetrin treatment, the tumors in 14% of the mice completely regressed for a period of 3 weeks. This was achieved with no significant weight loss in the animals. This represents more potent anti-tumor activity compared to historical data with standard leukemia chemotherapies, Vincristine or Daunorubicin, in a human xenograft model, e.g., Vincristine (0.2 mg/kg every other day for 1 week) reduced tumor volumes by 55% and Daunorubicn (1 mg/kg every other day for 2 weeks) reduced tumor volume by 30% in the MOLM-13 acute myeloid leukemia xenograft model (Yang 2007 Blood 110:2034).