I am still actively researching the components of the prurisol. As I go about this I am getting more and more excited about the prospects of this drug being used in other immunocompromised indications. Look at the IL-20 levels for the Prurisol vs. MTX.

Rheumatoid arthritis is one indication where MTX is a first line medication and there are currently other drug companies that are working actively on new medicines for IL-20 inhibitors as a treatment for rheumatoid arthritis. I am sure if I keep digging I can also correlate IL-20 research to all the other diseases we have been talking about.

Prurisol (10 mg/kg PO twice/ day x 21 days)

» 84% reduction in lesion appearance

» 99% reduction in lesions based on histology

 » 96% reduction in serum PRINS

 » 87% reduction in serum IL-20

 » No reoccurrence of lesions within 180 days »

Methotrexate (7.5 mg/kg IP once/ day x 5 days)

» 63% reduction in lesion appearance

» 76% reduction in lesions based on histology

» 48% reduction in serum PRINS

» 46% reduction in serum IL-20

» Lesions reoccurred in 61 days