Protocol for first dosing patients now that Kevetrin is being administered:

During each 4 week cycle, each patient will receive three weekly doses of Kevetrin given as
a 1 hour intravenous infusion followed by a 1 week off-treatment period. Following each
dose, each patient will be monitored. If the patients have acceptable safety and tolerance,
Kevetrin will be given once weekly for a total of 3 weeks. During each cycle patients will
be evaluated for safety, tolerance, and Dose-Limiting Toxicity (DLT) that occur during a
cycle.