start low doses and work up to test tolerance and toxicity. Sometimes people have been killed by their cancer drug treatment, long before their cancer would have killed them. We say Kevetrin is well tolerated according to animal studies, but in cancer drug world that includes nausea, diarrhea, vomiting, changes in blood count. Start high and you might kill someone prematurely. Start low and they might, hopefully show signs of some positive effect without showing harsh adverse effects.