Posted On: 10/25/2012 6:46:31 PM
Post# of 72436
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Re: NotRichYet2 #164
Hi NotRichYet,
Have not finished reading todays posts so perhaps this question has already been answered. They will check for p53 activation 7 hours after first does and 24 hours after first dose. This activation, evidenced by seeing p21 expression, will be confirmed on day one of dosing with each subject.
http://clinicaltrials.gov/ct2/show/NCT0166400...amp;rank=1
- Changes in the biomarker p21 in peripheral blood lymphocytes [ Time Frame: baseline and 7 hours ] [ Designated as safety issue: No ]
For biomarker analysis, p21 expression, assayed by qPCR, in peripheral blood lymphocytes after Kevetrin administration.
- Changes in the biomarker p21 in peripheral blood lymphocytes [ Time Frame: baseline and 24 hours ] [ Designated as safety issue: No ]
For biomarker analysis, p21 expression, assayed by qPCR, in peripheral blood lymphocytes after Kevetrin administration.
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