We are on the most reads! $CWNM The objective of intelligent drug delivery design is to maximize the percent of time that drug plasma levels are within the therapeutic range, thus avoiding patient exposure to potentially toxic or sub-therapeutic levels. This ideal pharmacokinetic profile reflects zero-order rate kinetics, defined as the constant release of drug into the circulation without dependency on the amount of drug remaining for delivery, with the option of an initial loading bolus to shorten the time to therapeutic plasma concentrations.