Pay attention. This one is starting to top buzz meters and the chart is setting up for something great! $CWNM The added value of controlled-release products is well documented in pharmaceutical literature, and its advantages cannot be understated. One such advantage is the ability to maintain targeted plasma concentrations of a drug over a defined and extended period of time by minimizing the peak-to-trough variations in drug concentration. In addition, the reduced frequency of required drug administrations per day is known to improve patient compliance and overall clinical utility.