Hi P, yes the smart trade would be to hold until FDA advisory mtg on Jan. 14. Depending on where the price is, you might want to hold some shares if it gets approval. I also really like MACK again for short-term trade. It's been beaten up and moving up. I really think IDRA has big longterm potential...big recent investments by Baker Bros and several other hedge funds. It has been a great day trader stock lately, but they have something going for psoriasis and cancer.... others have said the potential to be next ACAD or PCYC.... that would be huge!