Osivax Highlights Milestone in Influenza Vaccine Development
Osivax Reaches a Significant Milestone in Vaccine Development
Osivax, a pioneering biopharmaceutical company, has reached an important milestone in its clinical journey. The company has successfully completed final visits for all participants involved in the Phase 2a clinical booster trial, focusing on OVX836, its innovative broad-spectrum influenza A vaccine candidate. This notable announcement brings excitement as Osivax prepares to share its final results, anticipated in the upcoming H2 2025.
Understanding the Clinical Trial
The Phase 2a trial was conducted at the esteemed Center for Vaccinology (CEVAC), associated with Ghent University Hospital. As a single-center, randomized, double-blind study, it assessed the immunogenicity and safety of OVX836 when administered intramuscularly at two different dosages—180?g and 480?g. The trial consisted of 117 healthy adult volunteers, aged between 20 and 64, who had previously participated in prior Phase 2 trials featuring OVX836, Influvac Tetra, or a placebo.
Trial Success and Participant Involvement
Participants who had originally received a placebo or Influvac were given the highest dose of OVX836 as their primary vaccination, ensuring a robust control for the study. The involvement of participants has been vital to reaching this endpoint, and their contributions underscore the importance of collective efforts in advancing vaccine research.
Expert Insights from the Research Team
"Reaching the Last Patient Last Visit in this booster trial is a significant milestone for both our team and the field of influenza vaccine development," said Prof. Isabel Leroux-Roels, the Principal Investigator and Associate Professor at Ghent University. Her insights highlight the innovative approach of this study in evaluating immune responses to a new vaccination over time.
Dr. Nicola Groth, Chief Medical Officer of Osivax, emphasized that this undertaking is unique in its assessment of immune responses to a booster dose given years after initial vaccination. This perspective is crucial to understanding the durability and effectiveness of OVX836, further supporting the objective to create a comprehensive solution for influenza and respiratory viruses.
OVX836: A Groundbreaking Vaccine Candidate
OVX836 stands out as a first-in-class influenza A vaccine candidate. Unlike traditional vaccines that target rapidly mutating surface antigens, OVX836 focuses on the nucleoprotein (NP), a highly conserved internal antigen. This strategic focus significantly enhances the potential for a broader immune response. Moreover, Osivax's innovative oligoDOM technology allows for the self-assembly of a recombinant version of the NP into nanoparticles, which effectively elicits a robust T- and B-cell immune response.
Osivax's Vision for Future Vaccines
Osivax is on a mission to revolutionize how vaccines are developed for respiratory viruses. With a clinical foundation of over 1,400 participants involved across seven clinical trials, the company is gaining crucial data on the safety, efficacy, and immunogenicity of OVX836. Osivax's ultimate goal is to deliver a universal respiratory virus vaccine, which could potentially prevent all strains of influenza and various COVID-19 variants with a single administration.
In this rapidly evolving field, collaborations and expansions into other infectious disease domains are on Osivax’s strategic roadmap. The company is poised to make significant impacts and create long-lasting solutions to combat respiratory illnesses worldwide.
Contact Information
If you would like to learn more about Osivax and its efforts in vaccine development, please reach out directly to Alexandre Le Vert, CEO, at contact@osivax.com. You can also connect with their media relations team for inquiries at osivax@trophic.eu.
Frequently Asked Questions
What is the purpose of the OVX836 vaccine?
The OVX836 vaccine aims to provide broad-spectrum protection against various strains of influenza by targeting a conserved internal antigen.
When are the final results of the booster trial expected?
Final results from the booster trial are anticipated to be announced in H2 2025.
Where is the Phase 2a trial being conducted?
The clinical trial is being conducted at the Center for Vaccinology (CEVAC) at Ghent University Hospital in Belgium.
Who were the participants in the study?
The trial involved 117 healthy adult participants between the ages of 20 and 64, who previously took part in Osivax’s earlier studies.
What makes OVX836 different from traditional vaccines?
OVX836 focuses on the nucleoprotein, an internal antigen that mutations affect less frequently, potentially eliciting a more comprehensive immune response compared to traditional surface antigen-targeting vaccines.
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