Orocidin and Syngene Collaborate to Advance Peptide Production
Advancement of Peptide Manufacturing Through Collaboration
This partnership marks a significant milestone in addressing the complexities of peptide synthesis and purification, focusing on achieving both high yield and purity levels necessary for clinical applications.
Orocidin’s Breakthrough in cGMP Manufacturing
Orocidin A/S, a subsidiary of Nordicus Partners Corporation (OTCQB: NORD), has successfully developed a unique manufacturing process that complies with contemporary Good Manufacturing Practices (cGMP). This innovative approach is a result of teamwork with Syngene International Limited (Syngene), which specializes in integrated research, development, and manufacturing. This collaboration aims to ensure the production of high-quality peptides that meet the stringent requirements of clinical use.
The Significant Role of QR-01
QR-01, a 37-amino acid peptide, is designed to specifically target harmful bacteria, which makes it a potential treatment for aggressive periodontitis. Orocidin aims to initiate clinical trials with this peptide, necessitating a high-purity production process with minimal impurities.
Overcoming Technical Challenges
The synthesis of QR-01 is fraught with challenges owing to its chemical properties. The structure is rich in hydrophobic and basic amino acids, which can lead to aggregation issues that compromise yield during Solid-Phase Peptide Synthesis (SPPS). The N-terminal region, which includes multiple lysine and arginine residues, is particularly prone to incomplete reactions, which can hinder production quality.
Custom Solutions for Quality and Yield
To tackle these issues, the teams implemented a tailored synthesis and purification process. The use of a low-loading resin during SPPS minimized sequence-induced aggregation. Furthermore, the optimization of the chemical cleavage step was pivotal, successfully preventing the development of undesirable TFA adducts. The result of these efforts was a substantial increase in crude peptide purity to over 50%. Enhanced solubility also facilitated smoother purification processes.
Transitioning to Clinical-Grade Manufacturing
Impressively, Orocidin and Syngene achieved a seamless transition from laboratory-scale synthesis to cGMP manufacturing. The process yielded an impressive 10% production efficiency while adhering to clinical requirements, highlighting the proficiency of Syngene in establishing scalable peptide production methods.
Words from the Leadership
“We were greatly impressed with Syngene’s professionalism, commitment to excellence, and timely delivery of high-quality results,” remarked Allan Wehnert, CEO of Orocidin. This collaboration underscores the effectiveness of merging resources and expertise to innovate peptide production.
Orocidin’s Vision for the Future
Orocidin is dedicated to developing the most effective treatments for aggressive periodontitis. The firm’s novel therapeutic agent, QR-01, sets itself apart by effectively addressing both the inflammatory and bacterial aspects of this condition.
About Nordicus Partners Corporation
Nordicus Partners Corporation is recognized as the only U.S. publicly traded business accelerator dedicated to Nordic life sciences enterprises. With extensive experience in corporate finance, Nordicus facilitates business development, partnership formation, and talent acquisition among relevant companies. The company has expanded its portfolio, having acquired Orocidin and Bio-Convert A/S, further strengthening its position in the biotech landscape.
Frequently Asked Questions
What is QR-01?
QR-01 is a 37-amino acid peptide developed by Orocidin, targeting harmful bacteria and showing promise for the treatment of aggressive periodontitis.
What does cGMP mean?
cGMP stands for current Good Manufacturing Practices, standards ensuring that products are consistently produced and controlled according to quality standards.
Who is Syngene?
Syngene International Limited is a leading organization in research, development, and manufacturing services, collaborating with Orocidin on peptide production.
Why is peptide purity important?
High peptide purity is vital for clinical trials to ensure safety and effectiveness in therapeutic applications.
What are the future plans for Orocidin?
Orocidin aims to continue advancing its therapies for aggressive periodontitis, with QR-01 as a focal point for upcoming clinical trials.
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