Onward Therapeutics Expands Groundbreaking Onco-Metabolism Program
Onward Therapeutics Enters Global License Agreement for OT-S00X
In a significant advancement for cancer research, Onward Therapeutics SA has taken an important step by exercising its exclusive option and signing a worldwide license agreement with the prestigious Institut du Cancer de Montpellier (ICM). This partnership is set to propel their innovative program focusing on onco-metabolism toward new frontiers in cancer treatment.
The Foundation of Collaboration
This exciting license agreement is built on a previous collaboration initiated back in June 2021, where Onward Therapeutics France partnered with ICM, Inserm, and Université de Montpellier. During this collaboration, research funding was allocated to support an ambitious discovery program at ICM. The fruitful partnership has led to the identification of potent compounds and the seamless transition of these discoveries into Onward Therapeutics' drug development pipeline.
Progress and Development
The program, labeled OT-S00X, is an ambitious venture designed to expand treatment options for cancer. With preclinical studies yielding promising results, the candidates developed so far have shown strong efficacy. The focus of the program now shifts to lead optimization, where the team aims to identify candidates eligible for IND-enabling studies in the upcoming timeframe.
Innovative Approach to Cancer Treatment
Onward Therapeutics is making strides in cancer therapy through its onco-metabolism project, OT-S00X. Early studies have revealed a compelling connection between the efficacy of the compounds in development and a predictive biomarker of response across diverse tumor types. This groundbreaking research exemplifies a novel mechanism of action that targets metabolic strategies in tumors, aiming to overcome resistance seen with traditional therapies.
Expert Insights
Dr. Armand de Gramont, Chief Scientific Officer of Onward Therapeutics, highlighted the significance of OT-S00X by stating that it represents a substantial breakthrough in onco-metabolism. “The differentiated metabolic strategy introduced by OT-S00X allows us to broaden our pipelines, offering an innovative method to tackle the ongoing challenges of cancer resistance,” he noted.
The Role of ICM
Prof. Marc Ychou, Director General of ICM, expressed enthusiasm about the strengthened collaboration, emphasizing the potential of the OT-S00X program. He remarked, “This partnership shows the exciting possibilities of translational science in developing unique therapeutic strategies in oncology. Furthermore, it underscores the international reach of ICM and the noteworthy contributions of Montpellier MedVallée in fostering cancer innovation.”
About Onward Therapeutics
Onward Therapeutics is a forward-thinking clinical-stage biotechnology company concentrating on the development of novel cancer therapies. With a focus on translational science and prompt drug development, the company propels promising candidates through an expedited framework. Their portfolio consists of various innovative treatment candidates, including a bispecific antibody and an allogeneic NK cell therapy, alongside two promising first-in-class early development programs, one being the onco-metabolism project OT-S00X.
About Institut du Cancer Montpellier (ICM)
Established in 1923, ICM ranks among the 18 French Comprehensive Cancer Centers dedicated to patient care, research, and groundbreaking innovations. Managed by Prof. Marc Ychou, ICM integrates multidisciplinary patient management with cutting-edge research, ensuring an advanced spectrum of care. The affiliated research institution collaborates with Inserm and Université de Montpellier, fostering a partnership of over 200 researchers, recognized by the French National Cancer Institute as an Integrated Cancer Research Center (SIRIC).
Frequently Asked Questions
What is the purpose of the OT-S00X program?
The OT-S00X program aims to expand therapeutic options in cancer treatment through innovative onco-metabolism strategies.
Who is Onward Therapeutics?
Onward Therapeutics is a clinical-stage biotechnology company focused on developing leading-edge cancer therapies using a fast-track development model.
What is the significance of the collaboration with ICM?
The collaboration with ICM enhances Onward Therapeutics' research capabilities and accelerates the development of promising therapeutic candidates for cancer treatment.
How does OT-S00X differ from traditional treatments?
OT-S00X utilizes a unique metabolic strategy to target cancer, which aims to overcome issues with resistance that frequently occur with conventional therapies.
What future developments can we expect from Onward Therapeutics?
Onward Therapeutics is actively working on multiple early development programs, including innovative candidates in onco-metabolism and bispecific antibodies.
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