Leadership Changes at Hinge Bio to Accelerate GEM-DIMER™ Development
Strengthening the Leadership at Hinge Bio
Hinge Bio, Inc., a cutting-edge biotechnology company known for its innovative GEM-DIMER™ platform, is growing its leadership team to enhance its clinical development capabilities. The recent additions of Paul Brunetta, M.D., as Chief Medical Officer; Kristen Quigley as Chief Clinical Operations Officer; and Alpana Naresh, Ph.D., as Vice President and Head of CMC Strategy and Manufacturing, mark an exciting chapter in the company’s journey.
New Leadership Team Members
Dr. Paul Brunetta's Expertise
Dr. Brunetta arrives with a wealth of experience, having previously served as Senior Vice President at Sana Biotechnology. His extensive background in clinical drug development for autoimmune diseases includes a significant tenure at Genentech, where he spearheaded numerous clinical trials across various therapeutic areas. His expertise will be instrumental as Hinge Bio seeks to navigate complex clinical landscapes.
Kristen Quigley’s Clinical Insight
With nearly three decades of experience in clinical research, Kristen Quigley brings to Hinge Bio a proven track record of managing extensive clinical trial portfolios. Her leadership roles in both biotech firms and clinical research organizations demonstrate her commitment to enhancing patient outcomes through innovative research.
Dr. Alpana Naresh’s Manufacturing Knowledge
Dr. Naresh complements the team with her knowledge of CMC operations, having worked on development and manufacturing processes in both Harpoon Therapeutics and Merck. Her scientific acumen and collaborative approach would significantly contribute to Hinge Bio’s mission of bringing novel therapies to market.
Scientific Contributions and Data Publication
Recently, Hinge Bio made headlines with its publication in a scientific journal, where it shared groundbreaking preclinical data on its lead candidate, HB2198. This innovative dual-targeting bispecific antibody is aimed at achieving deep depletion of memory B cells, highlighting a key mechanism for treating autoimmune conditions such as systemic lupus erythematosus (SLE).
Impact of HB2198
The findings on HB2198 reveal its potential to revolutionize treatment strategies for autoimmune disorders. The data demonstrated significant depletion of targeted B cells, which is critical in managing multiple autoimmune diseases. The development of HB2198 aligns with Hinge Bio’s ultimate goal: to reset the immune system safely and effectively through an affordable, off-the-shelf therapy.
Future Prospects for Hinge Bio
With plans to begin clinical development for HB2198 in the near future, Hinge Bio is gearing up for a transformative phase. The focus on B cell-mediated autoimmune disorders signifies a strategic move towards addressing substantial unmet medical needs while employing advanced therapeutic modalities.
About Hinge Bio
Hinge Bio, Inc. is dedicated to creating the next generation of treatments that prioritize efficacy while minimizing side effects. By leveraging its proprietary GEM-DIMER™ platform, the company designs innovative therapeutic solutions targeting autoimmunity, inflammatory diseases, and cancer, aiming to deliver enhanced health outcomes for patients.
Frequently Asked Questions
What is the focus of Hinge Bio's new leadership team?
The new leadership team at Hinge Bio is focused on driving the clinical development of its innovative GEM-DIMER™ programs, particularly for autoimmune diseases.
Who are the new executives at Hinge Bio?
The new executives include Dr. Paul Brunetta as Chief Medical Officer, Kristen Quigley as Chief Clinical Operations Officer, and Dr. Alpana Naresh as Vice President, CMC Strategy and Manufacturing.
What is HB2198?
HB2198 is Hinge Bio's lead candidate designed to deplete memory B cells to treat autoimmune disorders like systemic lupus erythematosus (SLE).
When is the clinical trial for HB2198 expected to commence?
Hinge Bio anticipates initiating the clinical trial for HB2198 in the second half of 2025.
How does Hinge Bio's GEM-DIMER™ platform work?
The GEM-DIMER™ platform enables the creation of multispecific therapeutics that can bind to multiple targets simultaneously, enhancing biological activity and efficacy in treatment.
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