KROMATID Unveils Groundbreaking KROMASURE PinPoint Technology
KROMATID Launches KROMASURE PinPoint for Enhanced Genomic Analysis
With an aim to transform gene therapy development, KROMATID has unveiled its innovative KROMASURE PinPoint system. This next-generation platform revolutionizes transgene integration analysis by providing single-cell resolution that was previously unattainable. Researchers now have the ability to detect tiny integration events as small as 2kb across up to 1,000 individual cells in a single experiment, significantly raising the bar for analytical precision in the field of structural genomics.
Revolutionizing Insights into Gene Therapy
KROMATID, a leading name in structural genomics, has delivered an exceptional advancement in their Advanced Cytogenetics Platform with this release. KROMASURE PinPoint is designed specifically for the rigorous demands of cell and gene therapy development and delivers unparalleled insight into transgene insertional copy number and its distribution on a per-cell basis. This capability is particularly crucial for identifying low-prevalence events, often overlooked in traditional pooled assays.
Meeting the Needs of Modern Research
Erin Cross, VP of Platform at KROMATID, expressed enthusiasm about the product’s capabilities: "PinPoint is not just a product—it represents a fundamental shift in understanding transgene integration. Its high-resolution, interphase-capable design is perfectly suited for today’s needs in genomic analysis. The challenges of traditional methodologies are being addressed, especially in non-dividing cells where earlier techniques have often fallen short.”
A New Era in Transgene Integration Analysis
The historical reliance on sequencing and ddPCR for evaluating insertional copy number has its limitations, primarily due to their dependence on pooled cell populations. This obscures the critical cell-to-cell variability crucial for precise characterization. KROMATURE PinPoint takes a bold step forward by allowing the analysis of individual cells, thus enabling researchers to see small targets, visualize rare integration patterns, and get a true understanding of copy number distribution across cell populations.
Key Features of KROMASURE PinPoint
PinPoint not only enhances detection capabilities but also introduces several powerful features that empower researchers in transgene integration analysis:
- Precise Chromosomal Mapping: Accurately identifies integration loci on individual chromosomes.
- Single-Cell High-Throughput Analysis: Profiles up to 1,000 cells per run, capturing elusive low-prevalence events.
- Support Compliance and Risk Profiling: Facilitates informed regulatory assessments and safety evaluations.
- Enhanced Interphase Visualization: Enables detection of integrations in non-dividing cells, broadening the scope of cytogenetic analysis.
- Comprehensive Data Interpretation: Integrates seamlessly with KROMASURE InSite for holistic genomic insights.
About KROMATID
KROMATID stands at the forefront of cytogenetic precision as a trusted contract research organization (CRO). The company's commitment is to enhance the cell and gene therapy landscape through precise genomic integrity analysis solutions. The KROMASURE platform offers high-confidence, single-cell insights, filling significant gaps typically left by conventional sequencing methods. KROMATID supports biotechnological innovators, pharmaceutical companies, CDMOs, and academic researchers, all in their pursuit of breakthroughs and regulatory confidence in genomic medicine. Their dedication to data-driven innovation continues to fuel advancements that are shaping the future of human healthcare.
Frequently Asked Questions
What is KROMASURE PinPoint?
KROMASURE PinPoint is a high-throughput analytical platform designed for precise transgene integration analysis at the single-cell level.
How does KROMASURE PinPoint improve genomic analysis?
It enhances resolution, allowing the detection of integration events as small as 2kb and profiling up to 1,000 individual cells, leading to better insight in gene therapy development.
What are the key features of the KROMASURE system?
The system includes precise chromosomal mapping, single-cell high-throughput analysis, risk profiling for compliance, and integrated data interpretation for comprehensive insights.
Who can benefit from KROMATID’s services?
Biotech firms, pharmaceutical companies, contract development and manufacturing organizations, and academic researchers can all leverage KROMATID's services to enhance their research in genomic medicine.
Why is single-cell resolution important?
Single-cell resolution allows researchers to understand the variability among individual cells, which is crucial for accurate characterization in gene therapy development.
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