Jeito Capital Pioneers $67.5 Million Investment in Gene Therapy

Jeito Capital Leads Significant Investment for Cardiovascular Innovation

Jeito Capital is excited to announce that it is leading a substantial funding round of $67.5 million aimed at advancing novel gene therapies in cardiovascular disease. This significant investment is not just a financial commitment; it's a strategic initiative intended to unlock innovative treatments for patients suffering from severe cardiovascular conditions.

Supporting Clinical Trials for XC001

The funds raised through this Series B financing round will facilitate critical double-blinded Phase 2 trials for XC001, a groundbreaking gene therapy candidate. This novel approach is designed to address significant unmet treatment needs for patients with severe cardiovascular diseases. Jeito Capital, known for its expertise in the field of cardiology, acknowledges the urgent need for effective therapies in this medically underserved area.

Collaborative Efforts with XyloCor Therapeutics

XyloCor Therapeutics, the biopharmaceutical company behind XC001, is dedicated to developing innovative gene therapies that could potentially transform the landscape of cardiovascular treatment. The collaboration with Jeito Capital signifies a shared vision to expedite the enhancement of patient care through advanced medical innovations.

Fund Allocation and Future Trials

Proceeds from the financing will specifically support the randomized, double-blind Phase 2b clinical trial known as EXACT-2. This trial will evaluate XC001 (encoberminogene rezmadenovec) for patients suffering from refractory angina. By employing a new non-surgical technique for administering the therapy via an injection catheter, XyloCor aims to elevate therapeutic outcomes for those who have limited options left for their condition.

Additional Research Initiatives

In addition to the Phase 2b trial, the funding will also enable a second Phase 2 trial where XC001 will be administered as an adjunctive treatment during coronary artery bypass graft (CABG) surgery. This trial aims to enhance blood flow in heart regions not directly targeted by the bypass, with the goal of improving patient outcomes significantly.

Commitment to Cardiovascular Health

Cardiovascular diseases remain a leading cause of mortality worldwide. Jeito Capital's commitment to this therapeutic area reflects its dedication to fostering the development of breakthrough therapies that can significantly alter the prognosis for patients facing debilitating cardiovascular issues.

Expert Insights from Jeito Capital

Dr. Rafaèle Tordjman, the Founder and CEO of Jeito Capital, expressed enthusiasm about XyloCor's potential, stating that the innovative gene therapy represents a strategic growth avenue for the firm. She articulated her excitement about collaborating with an experienced team within XyloCor to foster advancements that may change the lives of many patients.

About Jeito Capital and XyloCor Therapeutics

Jeito Capital is recognized globally for its patient-centric approach to private equity, focusing primarily on biopharmaceutical advancements. The firm actively invests not only capital but also expertise to expedite the market entry of pioneering medical therapies, particularly in Europe and the United States.

On the other hand, XyloCor Therapeutics is on a mission to develop best-in-class gene therapies, with XC001 currently leading their nascent pipeline. The firm is committed to enhancing the treatment landscape for patients suffering from ischemic heart conditions and strives for a future where effective therapeutic options are widely available.

Frequently Asked Questions

What is the primary goal of the investment by Jeito Capital?

The investment aims to support clinical trials for XC001, a gene therapy candidate, to improve treatments for cardiovascular diseases.

What are the details of the Phase 2 trials funded by this investment?

The funding will support two double-blinded Phase 2 trials for XC001, focusing on refractory angina and as an adjunct during CABG surgery.

How does XC001 differ from existing cardiovascular treatments?

XC001 represents a one-time gene therapy approach that aims to address unmet needs in patients who have exhausted traditional treatment options.

What is the significance of Jeito's expertise in this investment?

Jeito's experience in cardiology enhances the strategic development of breakthrough therapies, ensuring focused clinical advancements in this critical medical area.

When are the Phase 2 trials expected to commence?

The first patient is planned to be dosed by the end of 2025, as XyloCor prepares to launch the trials.

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