Jeito Capital Boosts Aviceda Therapeutics with $207.5M Funding

Jeito Capital's Strategic Investment in Aviceda Therapeutics

Jeito Capital has recently announced a significant investment in Aviceda Therapeutics, securing a substantial participation in an upsized $207.5 million Series C financing round aimed at advancing the company's lead program, AVD-104. This funding is specifically intended to support pivotal trials for AVD-104, which targets geographic atrophy, a serious condition that can lead to vision loss due to age-related macular degeneration (AMD).

Advancing AVD-104 into Pivotal Trials

The newly raised capital will bolster the ongoing Phase 2b/3 clinical trial of AVD-104 and its planned pivotal Phase 3 study. Currently, the Phase 2b/3 trial is fully enrolled with expectations for primary endpoint data to be available in the latter part of 2025. This showcases AVD-104's potential as an innovative treatment for patients suffering from geographic atrophy, a condition that currently has limited effective therapies.

Investment Details and Strategic Leadership

Jeito Capital's participation underscores its commitment to the ophthalmology sector, particularly following its previous successful exit with EyeBio. The financing round was co-led by notable healthcare investment firms, including Omega Funds and TCGX, alongside Jeito Capital and Enavate Sciences. Other prominent investors included Blue Owl Healthcare Opportunities and OrbiMed, all bringing together a wealth of expertise to fast-track Aviceda's development within both US and European markets.

AVD-104's Therapeutic Potential

AVD-104 utilizes a dual mechanism of action that targets immune modulation and complement inhibition. Preliminary results from earlier trials indicate its effectiveness in slowing GA lesion growth while preserving or even enhancing visual function. This promising data positions AVD-104 as a potential leader in the therapeutic landscape for geographic atrophy.

New Board Appointments and Future Directions

As part of this investment, two key members from Enavate Sciences, Rafaèle Tordjman and Sara Nayeem, will join Aviceda's Board of Directors as Board Observers. Their expertise is expected to provide valuable insights as Aviceda navigates this crucial phase of growth and development in its clinical programs.

Jeito Capital’s Commitment to Biopharma Innovation

Jeito Capital, with its headquarters in Paris, is dedicated to driving forward biopharma innovations. With a robust understanding of the healthcare landscape, especially in Europe and the United States, Jeito's investment approach is patient-benefit driven. With €534 million under management, Jeito seeks to cultivate leaders in their respective therapeutic areas, ensuring rapid access for patients to groundbreaking treatments.

The Impacts of Jeito's Expertise

Dr. Rafaèle Tordjman, the founder and CEO of Jeito Capital, expressed his commitment to Aviceda’s success, noting that their investment exemplifies Jeito's ambition to nurture promising biopharma companies capable of making significant impacts in patient care. He highlighted the importance of collaborative efforts to enhance the transformative potential of therapies like AVD-104.

Conclusion: A Positive Outlook for Aviceda and Its Investors

With this round of financing, Aviceda is well-positioned to advance the pivotal trials of AVD-104, generating excitement among investors who believe in its potential to disrupt current treatment paradigms in the field of ophthalmology. The strategic involvement of leading firms, coupled with Jeito Capital’s deep experience and resources, sets a solid foundation for future success.

Frequently Asked Questions

What is AVD-104 and how does it work?

AVD-104 is an ophthalmic therapy designed to treat geographic atrophy by employing dual mechanisms to modulate inflammation and inhibit the complement system involved in disease progression.

Which clinical trials is Aviceda currently conducting?

Aviceda is conducting a Phase 2b/3 trial for AVD-104, with full enrollment completed and results expected in the latter half of 2025.

Who are the major investors in this financing round?

The financing round saw participation from significant institutional investors including Jeito Capital, Omega Funds, and TCGX, among others.

What is the strategic importance of Jeito Capital's investment?

Jeito Capital's investment brings both financial support and strategic expertise, particularly in navigating the European healthcare landscape, which is vital for Aviceda’s development goals.

What does this investment mean for patients?

This investment provides the necessary capital to continue advancing AVD-104, offering hope for new, effective treatment options for patients suffering from geographic atrophy.

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