Invivyd Reports Strong Neutralizing Effect of PEMGARDA™ Against New COVID Variants

Understanding PEMGARDA's Efficacy Against SARS-CoV-2 Variants

Recent laboratory findings confirm the ongoing neutralizing capability of PEMGARDA™ (pemivibart), demonstrating its effective response against the prevalent SARS-CoV-2 variant known as XEC. This striking evidence illustrates how PEMGARDA remains potent even with the continuous mutation of the virus.

The Significance of New Data

The latest in vitro tests reveal that PEMGARDA maintains a consistent neutralizing effect against emerging variants, reinforcing its critical role in combating COVID-19. The Centers for Disease Control highlights that XEC and another variant, KP.3.1.1, collectively make up a significant portion of circulating SARS-CoV-2 strains across the U.S. This data underscores the effectiveness of PEMGARDA and emphasizes the importance of continued vigilance in tracking viral evolution.

PEMGARDA's Continued Resilience

Much has been learned over the past few years about the adaptation of the SARS-CoV-2 virus. Invivyd, Inc. is at the forefront of this research, continuously monitoring these changes. Their new results indicate that as long as the targeted epitope of pemivibart remains structurally stable, there is no reason to predict a decline in neutralization efficiency. This structural integrity has proven resilient since the emergence of the Omicron BA.1 variant.

Innovative Approaches to Viral Challenges

Robert Allen, Ph.D., the Chief Scientific Officer at Invivyd, remarks on their innovative design approach. The company's strategy aims to create antibodies like pemivibart that withstand viral evolution. Achieving successful neutralization against thirty-nine distinct variants over the years reassures public health experts about the reliability and future applications of PEMGARDA in treating COVID-19-related issues.

Invivyd's Commitment to Public Health

Invivyd has asserted that its tools and methodologies are prepared to address new viral variants as they surface. The positive outcomes from these neutralization assays include their ongoing dedication to evolving their antibody technologies, thus ensuring robust responses to current and future viral threats.

Promising Prospects for Immunocompromised Individuals

The prolonged effectiveness of PEMGARDA is especially critical for individuals with moderate to severe immune compromise. Health professionals note that the continuous mutations of SARS-CoV-2 necessitate constant reevaluation of treatment methodologies, emphasizing the importance of drugs such as PEMGARDA for these vulnerable populations. As COVID-19 cases potentially climb during certain seasons, the relevance of PEMGARDA as a treatment option grows more critical.

Anticipated Updates and Future Directions

Recent findings have been submitted to the FDA as part of the commitment to keep health providers informed. A timely update to the PEMGARDA Fact Sheet for Healthcare Providers is expected soon, ensuring that all medical personnel are equipped with the latest information about this investigational drug.

Exploring VYD2311 as a Future Solution

In addition to PEMGARDA, Invivyd is developing VYD2311, another promising monoclonal antibody candidate that targets COVID-19. This new candidate aims to address the need for treatment options specifically aimed at immunocompromised individuals who require additional protection against the virus. VYD2311’s extensive safety data and positive outcomes in trials offer hope as the company seeks to broaden its impact in viral disease prevention and treatment.

Reiterating Invivyd’s Mission

Invivyd, Inc. continues its mission to deliver innovative solutions against serious viral infectious diseases. The company employs advanced methodologies within its proprietary INVYMAB™ platform for the rapid generation of new monoclonal antibodies. By combining cutting-edge modeling with sophisticated viral surveillance, Invivyd seeks to provide the most effective and reliable solutions in the market.

Contact Information for Further Inquiries

For those interested in additional information, Invivyd’s media and investor relations teams are available. Media inquiries can be directed to Invivyd’s media relations at (781) 208-0160 or via email. Investors can reach out to the investor relations team, also at (781) 208-0160. Both teams are eager to assist with questions related to PEMGARDA™ (pemivibart) and VYD2311.

Frequently Asked Questions

What is PEMGARDA and how does it work?

PEMGARDA™ (pemivibart) is an investigational monoclonal antibody designed to neutralize SARS-CoV-2 by targeting the spike protein receptor binding domain.

What variants does PEMGARDA target effectively?

PEMGARDA has demonstrated neutralizing activity against major variants of concern, including XEC and KP.3.1.1, ensuring robust protection amid viral evolution.

Who can benefit from PEMGARDA?

This antibody is particularly critical for moderately to severely immunocompromised individuals who may not respond adequately to vaccination alone.

How long has PEMGARDA been in development?

PEMGARDA has been under evaluation for nearly three years, consistently showing neutralizing activity against numerous SARS-CoV-2 variants.

Will there be further updates on PEMGARDA's effectiveness?

Yes, data has been submitted to the FDA, and updates to the PEMGARDA Fact Sheet for Healthcare Providers will be issued soon.

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